It depends on what you're doing. In general, I'd say college (in the US I assume) tends to be watered down and is almost always just regurgitating information. At times the sheer volume of new information may be difficult to absorb, but rarely does it require hard thinking.
For most fields, college is a bubble which is well-insulated from the real world. Even if you studied STEM, most of what you learned in college will probably be outdated or irrelevant to your job, so when you start a new job you'll have to undergo a period of learning how everything actually works which may be overwhelming.
However, once you get past that adjustment period, white collar jobs tend to not be demanding in terms of work. Rarely will you have to learn something new, it'll just be doing the same tasks over and over. And you'll get better at it to the point you can get everything done well before the day is over.
Do bear in mind that when you encounter a new problem, you'll have to think it through yourself rather than rely on someone to spoonfeed you the answer, which few people can do after 16+ years in an education complex which prioritizes rote memorization. But in my experience new problems rarely emerge unless you're doing cutting-edge work.
said, most effort will probably go into dealing with your coworkers. God forbid if you work with a lot of succubi, which I did at my previous job. Then dealing with the drama and incompetence will be a daily struggle. If you work with a bunch nerds things will be much better, but then there can be the problem of a lack of communication.