Yes, but only if you have imagination and are willing to read extra/dig into the show. Some people like >>34601
can't understand that SEL truly doesn't want to be "scifi" or any other genre. Lain doesn't care about plot, characters, setting, or anything like that really. There are only two things SEL cares about: it's themes and the feeling it presents with it's atmosphere. If you value plot, coherent world building, and such related things above all else then you will dislike SEL. It's not that kind of show, and doesn't even attempt to be. The aspects it cares about, man does it fucking hit them with a homerun. Like perfect 11/10 tier.
The blending of internet and reality, if one is who they think they are, if who others say they are is who they are, if their actions are who they are, the social isolation that internet brings, the strange groups or cults that appear because extreme people segregate with other extreme people on the internet, and much more. Lain IS deep, regardless of whatever insincere ironic shitposters say; but only for those who put effort into finding things for themselves. "Deep" shows mean exactly what they mean, that it requires effort to uncover or dig up what it has to offer. If want to watch it once and understand everything, then don't bother with deep shows.
Being deep doesn't mean it's good, but people like deep shows because you have to put yourself into what you are consuming. It's not just "someone else's story", it's almost become something you discovered and crafted while digging into it. Your interpretations of the stories and events are now attached to the story, so you become attached to that thing you did not create. Which is why people who enjoy SEL will tell you they LOVE LAIN.